Peptide Nomenclature: Reading Amino-Acid Sequences

Peptides are chains of amino acids, commonly represented by one-letter or three-letter codes. Sequence notation normally runs from the amino terminus to the carboxyl terminus. Chemical modifications, disulfide bonds and terminal groups can substantially change molecular properties, so a familiar name may not fully describe the tested material. Researchers also distinguish a peptide's sequence from its salt form, purity and net content. Accurate nomenclature improves reproducibility and reduces confusion when comparing papers, certificates and analytical reports.